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Go Beyond the Angiogram

Comprehensive Physiology Indices

Go Beyond the Angiogram
Physiology Indices

Why Using Physiological Indices Is Essential

Physiological measurements, including hyperaemic (FFR) and non-hyperaemic pressure ratios (NHPR), Index of Microcirculatory Resistance (IMR), and Coronary Flow Reserve (CFR) are used to assess for epicardial disease and microvascular dysfunction. Physiologic data from PressureWire™ X Guidewire leads to informed decision-making that is proven to improve patient outcomes and prevent unnecessary, repeat hospitalisations.1

Physiological Indices Defined

Objective Diagnosis of Epicardial Disease and Microvascular Dysfunction

View how PressureWire™ X Guidewire measures Fractional Flow Reserve (FFR), Resting Full-cycle Ratio (RFR), Index of Microcirculatory Resistance (IMR) and Coronary Flow Reserve (CFR).

 

Assessing the Microcirculation

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Physiology Indices

Physiology-Guided Decision Making Leads to Better Outcomes

Determining the Need for Revascularisation
Determining the Need for Revascularisation
Assessment for a Coronary Microvascular Dysfunction Diagnosis
Assessment for a Coronary Microvascular Dysfunction Diagnosis

Society Guidelines for Physiologic Indices

 Diagnosing Epicardial StenosisDiagnosing Coronary Microvascular Dysfunction
 FFRRFRIMRCFR
GuidelinesACC/SCAI (view here)
ESC Guideline 2019 (view here)
AHA/ACC Guidelines (view here)
Cutoff Value≤ 0.82≤ 0.893≥ 251,*< 2.51,*
FormulaPd/Pa at hyperaemiaLowest Pd/Pa ratio of whole-cyclePd x Hyperaemic FlowHyperaemic Flow/Baseline Flow
HyperaemiaYesNoYesYes

*IMR and CFR cutoffs in population of ischaemia with no obstructive coronary artery disease (INOCA) patients, CorMicA trial.1

RFR is recognised by the Appropriate Use Criteria with an approved coding recommendation by ACC/SCAI.

Assessing whether Epicardial Stenosis needs intervention because there's more to CAD than an angiogram shows

Assessing Coronary Microvascular Dysfunction (CMD) because CMD may contribute to recurrent angina

References

  1. Ford TJ, et al. 1-year outcomes of angina management guided by invasive coronary function testing (CorMicA). J Am Coll Card Intu. 2020;13:33-45.
  2. Jeremias A, et al. A test in context: fractional flow reserve: accuracy, prognostic implications, and limitations. J Am Coll Cardiol. 2017;69(22):2748-2758.
  3. Kobayashi Y, et al. Agreement of the resting distal to aortic coronary pressure with the instantaneous wave-free ratio. J Am Coll Cardiol. 2017;70(17):2105-2113.

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