Quartet

Quadripolar LV Lead

Clinical Evidence

About

Quartet Quadripolar LV Lead

More pacing flexibility without compromising lead stability.

Built on the proven QuickFlex™ µ lead platform, the Quartet™ quadripolar LV lead offers superb deliverability with exceptional stability and performance. Studies reflect an implant success rate averaging approximately 97%.^1,2

Better Management of Heart Failure Symptoms

We designed our groundbreaking quadripolar technology to enable improved management and outcomes for HF patients. With four electrodes and up to 14 pacing configurations, the quadripolar system enables left ventricular (LV) pacing at the preferred site without compromising lead stability, for better management of heart failure patients.³

HF patients who undergo implantation of unipolar and bipolar CRT devices may experience challenges such as phrenic nerve stimulation, high pacing thresholds and non-response to CRT therapy.⁴ Managing these challenges can result in longer implant times and surgical revisions.

Quadripolar technology can help you overcome these challenges by offering you more pacing flexibility without compromising lead stability.

Potential Benefits of Quadripolar Technology

Shorter implant times and decreased fluoroscopic exposure^1,5
Fewer surgical revisions²
More basal pacing opportunities (pacing basally has been shown to be associated with improved outcomes)^6,7

Overall, quadripolar technology can lead to greater CRT implant and postoperative efficiencies while providing improved CRT efficacy.

MRI Readiness

The Quartet quadripolar LV lead, when combined with approved devices, allows full-body, 1.5T and 3T MRI scans that meet certain scan conditions.*

Meets industry-standard MRI testing requirements
Capable of full body 1.5T and 3T MRI imaging scans

Multiple Shape and Spacing Options

Distal shape options include the Double Bend shape, Traditional S-shape, Traditional S-shape—wide spacing and Small S-shape.
Total electrode spacing options include 40, 47 and 60 mm.

Four Quartet quadripolar LV lead shape options

Four Distinctly Spaced Electrodes

Enables greater pacing flexibility than unipolar or bipolar leads
Provides more options to help prevent pacing complications

IS4 Connector

Enables four pacing electrodes in a single connector for streamlined implantation

Low Profile

4.7 F lead body diameter for maneuverability
4.0 F tip electrode, which aids access to small targets or difficult-to-reach branch veins

Steerable Tip

Adjustable distal tip angle for enhanced maneuverability in venous anatomy

Optim™ Lead Insulation

First-of-its-kind hybrid insulation material
Developed specifically for cardiac lead use
Blends the biostability and flexibility of high-performance silicone rubber with the strength, tear resistance and abrasion resistance of polyurethane, allowing for superior abrasion resistance in a thin diameter lead⁸

Manuals & Resources

Cardiovascular Products

Customer Service

*See MRI Ready Systems Manual for device and lead combinations and associated MRI scan parameters. Quartet quadripolar LV Lead is MR Conditional in the 86cm lead length.

References

Sperzel, J., Dänschel, W., Gutleben, K. J., Kranig, W., Mortensen, P., Connelly, D., … Rinaldi, C. A. (2012). First prospective, multi-centre clinical experience with a novel left ventricular quadripolar lead. Europace, 14(3), 365-372
Forleo, G. B., Della Rocca, D. G., Papavasileiou, L. P., Molfetta, A. D., Santini, L., & Romeo, F. (2011). Left ventricular pacing with a new quadripolar transvenous lead for CRT: Early results of a prospective comparison with conventional implant outcomes. Heart Rhythm, 8(1), 31-37. https://dx.doi.org/10.1016/j.hrthm.2010.09.076
Data compiled from clinical study results, on file in Report 60034670.
Thibault, B., Dubuc, M., Guerra, P. G., Karst, E., Ryu, K., Paiement, P., … Farazi, T. (2011). Electrode selection to avoid phrenic stimulation with a quadripolar left heart lead. Heart Rhythm, 8(5), S68. https://dx.doi.org/10.1016/j.hrthm.2011.03.023
Duray, G. Z., Hohnloser, S. H., & Israel, C. W. (2008). Coronary sinus side branches for cardiac resynchronization therapy: Prospective evaluation of availability, implant success, and procedural determinants. Journal of Cardiovascular Electrophysiology, 19(5), 489-494. https://dx.doi.org/10.1111/j.1540-8167.2007.01096.x
Singh, J. P., Klein, H. U., Huang, D. T., Reek, S., Kuniaa, M. Quesada, A., … Moss, A. J. (2011). Left ventricular lead position and clinical outcome in the Multicenter Automatic Defibrillator Implantation Trial Cardiac Resynchronization Therapy (MADIT-CRT) trial. Circulation, 123(11), 1159-1166. https://dx.doi.org/10.1161/CIRCULATIONAHA.110.000646
Merchant, F. M., Heist, E. K., McCarty, D., Kumar, P., Das, S., Blendea, D., … Singh, J. P. (2010). Impact of segmental left ventricle lead position on cardiac resynchronization therapy outcomes. Heart Rhythm, 7(5), 639-644. https://dx.doi.org/10.1016/j.hrthm.2010.01.035
Jenney, C., Tan, J., Karicherla, A., Burke, J., & Helland, J. (2005). A new insulation material for cardiac leads with potential for improved performance. Heart Rhythm, 2(5), S318-319. https://dx.doi.org/10.1016/j.hrthm.2005.02.1004

MAT-2212652 v1.0

CARDIOVASCULAR