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Peripheral Artery Disease (PAD)

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Looking for Information on Peripheral Artery Disease?

Learn about this condition, including what it is, who could be at risk, symptoms, how it is diagnosed, and available treatments

 

To learn about PAD, click on the sections you want to explore or know more about:
 

What is PAD and what are its symptoms?

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Symptoms of Peripheral Artery Disease (PAD)

Who is at risk
of PAD?

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Peripheral Artery Disease (PAD) Risk Factors

How is PAD diagnosed and treated?

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How is Peripheral Artery Disease (PAD) Diagnosed

More information
on PAD

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Peripheral Artery Disease (PAD) Resources

What is Peripheral Artery Disease (PAD)?

  • PAD is a common condition affecting the legs1,2
  • In PAD, a build-up of fatty deposits (plaque) in the leg arteries restricts blood flow from the heart to the legs1,2
  • When blood flow is reduced, this can lead to leg pain when walking or climbing stairs because your leg muscles aren't getting enough oxygen2,3
  • PAD can also prevent sores on the feet or legs from healing, which can develop into areas of dead tissue (gangrene) that ultimately may lead to amputation of the foot or leg4,5
  • PAD may progress to an advanced form known as chronic limb-threatening ischemia (CLTI), incurring significant limb loss, pain, decreased quality of life, and mortality6
What is Peripheral Artery Disease (PAD)

PAD Patient Brochure

In this Brochure You Will Find More Detailed Information About PAD.

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Peripheral Artery Disease (PAD) Information Download

What are the Symptoms of PAD?

PAD symptoms don't present the same way in every patient4,5

  • In lower leg PAD, symptoms may include muscle fatigue, cramping, and/or pain in the legs during exercises that stop after resting, which is called “intermittent claudication”4,5
  • Symptoms of an advanced form of PAD include pain in the toes or feet even while resting, sores on the toes, feet, or legs that don't heal, and leg numbness or weakness4,5
  • Symptoms of CLTI include the presence of PAD in combination with pain at rest, gangrene, or ischemic ulcerations persisting for a duration >2 weeks6

Most patients have no PAD symptoms and are not aware that they have PAD7

Who is at Risk of PAD?

There are certain conditions, known as risk factors, that may contribute to the development of peripheral artery disease (PAD). The risk factors for PAD include:5,8,9

Who is at Risk for Peripheral Artery Disease (PAD)

Being over 65 years of age

Peripheral Artery Disease (PAD) Age Risk Factor


Having a family history of PAD

Peripheral Artery Disease (PAD) Family Risk Factor


Smoking

Peripheral Artery Disease (PAD) Smoking Risk Factor


High Blood Pressure

Peripheral Artery Disease (PAD) High Blood Pressure Risk Factor


High Cholesterol

Peripheral Artery Disease (PAD) High Cholesterol Pressure Risk Factor


Diabetes

Peripheral Artery Disease (PAD) Diabetes Risk Factor


Obesity

Peripheral Artery Disease (PAD) Obesity Risk Factor

Despite advances in risk factor management and best medical therapy, PAD and especially CLTI are associated with markedly increased cardiovascular morbidity and mortality.6

How is PAD Diagnosed?

To diagnose PAD, a physical examination is performed. If PAD is suspected, this may be followed by a specific blood pressure measurement.

Who is at Risk for Peripheral Artery Disease (PAD)

Physical Examination

  • May include an examination of the head, neck, skin, nerves, muscles, heart, lungs, abdomen, lower legs, and feet5
  • Measurement of blood pressure, body temperature, breathing, and heart rate5
Peripheral Artery Disease (PAD) Obesity Risk Factor

Ankle Brachial Index (ABI)

When PAD is suspected, an ABI compares the blood pressure in the legs to the arm and is a useful way of confirming PAD diagnosis, especially when symptoms are atypical or absent.1,5,10

Ankle Brachial Index for Peripheral Artery Disease Diagnosis

Timely diagnosis and treatment of PAD is very important to prevent progression to advanced stages, amputation and development of serious cardiovascular complications5,6

How is PAD Treated?

PAD can be managed through a combination of lifestyle changes and various treatments5,11

Lifestyle changes

including quitting smoking, adapting diet, and practicing regular exercise

Peripheral Artery Disease (PAD) Obesity Risk Factor


Medications

such as medications to treat high cholesterol, high blood pressure, or diabetes

Peripheral Artery Disease (PAD) Obesity Risk Factor

Minimally invasive procedures

such as inserting a small tube (stent) to open blood vessels

Peripheral Artery Disease (PAD) Obesity Risk Factor

Surgery

Peripheral Artery Disease (PAD) Obesity Risk Factor

Patients can support their PAD treatment, which may influence outcomes, by paying attention to lifestyle modifications and following medication regimens prescribed by their doctor

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Contact
Your Doctor

Peripheral artery disease (PAD) is a condition affecting the blood vessels in the legs that commonly presents in people over the age of 65, or younger for those with existing cardiovascular risk factors. If left untreated, PAD can lead to serious long-term complications. If diagnosed early and treatment started quickly, the risk of these complications can be reduced significantly.

Peripheral Artery Disease (PAD) Obesity Risk Factor

If you have any questions or concerns about PAD, or think that you or someone you know may be at risk of PAD, do not hesitate to contact your doctor for further information

 

The information provided is not intended for medical diagnosis or treatment or as a substitute for professional medical advice.
Consult with a physician or qualified healthcare provider for appropriate medical advice.

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References:

  1. Hirsch AT, et al. JAMA. 2001; 286(11): 1317-24.
  2. Centers for Disease Control and Prevention. Peripheral Arterial Disease (PAD) 27 Sep 2021. Accessed May 2022.
  3. Cleveland Clinic. Peripheral Artery Disease (PAD). 19 January 2022. Accessed May 2022.
  4. Shu J, Santulli G. Atherosclerosis. 2018; 275: 379-81.
  5. Gerhard-Herman MD, et al. Circulation. 2017; 135(12): e686-7256.
  6. Conte MS, et al. J Vasc Surg. 2019; 70(2): 662.
  7. Virani SS, et al. Circulation. 2021; 143(8): e254-743.
  8. Steffen LM, et al. Diabetes Spectr. 2008; 21(3): 171-7.
  9. Hirsch AT, et al. Circulation. 2006; 113(11): e463-654.
  10. Criqui MH, et al. J Am Coll Cardiol. 2008; 52(21): 1736-42.
  11. Wu A, et al. J Am Heart Assoc. 2017; 6(1): e004519.

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